Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

نویسندگان

  • J.W.M. van der Linden
  • M.C. Arendrup
  • A. Warris
  • K. Lagrou
  • H. Pelloux
  • P.M. Hauser
  • E. Chryssanthou
  • E. Mellado
  • S.E. Kidd
  • A.M. Tortorano
  • E. Dannaoui
  • P. Gaustad
  • J.W. Baddley
  • A. Uekötter
  • C. Lass-Flörl
  • N. Klimko
  • C.B. Moore
  • D.W. Denning
  • A.C. Pasqualotto
  • C. Kibbler
  • S. Arikan-Akdagli
  • D. Andes
  • J. Meletiadis
  • L. Naumiuk
  • M. Nucci
  • W.J.G. Melchers
  • P.E. Verweij
چکیده

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

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عنوان ژورنال:

دوره 21  شماره 

صفحات  -

تاریخ انتشار 2015